为探究 STING 对 CD8? T 细胞代谢的影响，东南大学等单位研究人员开展相关研究。结果发现 STING 通过 HK2 / 乳酸 / IFN-γ 轴影响 CD8? T 细胞功能和记忆分化。该研究为 STING 低表达患者提供新治疗策略，值得科研读者一读。 在肿瘤治疗的战场上，能量代谢的研究正 ...

a lysosomal protein specifically expressed in CD8 + T cells, inhibits mTORC1 function via the lysosomal proton pump, vacuolar ATPase, promoting antitumor activity and expansion of memory T cell ...

These effects require prior TCR engagement. This restriction to antigen-stimulated T cells and a more pronounced expansion of memory CD8+ T cells differentiates TNFRSF25 from other T cell ...

CloneTrack, a sequencing-based tool, identified 79 vaccine-induced CD8 + T cell clones in responders. Clones induced during priming doses reached peak expansion after six or fewer doses ...

Certain immune cells in MS show abnormalities in activity and signs of reactions against the Epstein-Barr virus, a study says ...

CD8+ T cells accumulate in atherosclerotic plaques. LMU researchers identify a crucial signaling pathway - with therapeutic potential. Atherosclerosis is the most common cause of life-threatening ...

More information: Shijun Ma et al, Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity, Cancer Cell (2024). DOI: 10.1016/j.ccell.