Here, we report that signalling through endogenous CD2 following ligation with its ligands, CD48 in mouse and CD58 in humans, drives IL-2 production by first-generation CD19-specific CAR.

All these receptors are type I transmembrane proteins with the exception of the glycosyl-phosphatidylinositol (GPI)–linked CD58 isoform and CD48. All CD2 family members that possess cytoplasmic ...