Dr. Sun concludes: "Mechanistically, we found that CD44 deficiency downregulates tryptophan hydroxylase 2 expression in white adipose tissue, leading to reduced serotonin (5-HT) levels ...

The intracellular domain of CD44 (CD44-ICD) stimulates the expression of tryptophan 5-hydroxylase 2 (Tph2) in white adipocytes, leading to the production of serotonin (5-HT). This 5-HT ...

Dr. Sun concludes, "Mechanistically, we found that CD44 deficiency downregulates tryptophan hydroxylase 2 expression in white adipose tissue, leading to reduced serotonin (5-HT) levels ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...