生物通26 天
Single-cell RNA-seq 数据存在普遍血液污染，Originator 工具来 “救场”
对 B 细胞、CD4 T 细胞、CD8 T 细胞和 NK 细胞的平均 F 分数分别达到 0.98、0.93、0.91 和 0.99 。 血液免疫细胞在组织样本中的普遍存在：应用 Originator 对多个公开的 scRNA-seq 数据集分析发现，大多数组织样本中的免疫细胞主要来自血液，而非组织微环境。这一结果表明 ...
生物通9 天
MTBVAC 结核疫苗早期免疫应答特征：γδ T 细胞与 CD4 淋巴细胞的关键作用
结核病（TB）仍是全球重大健康问题，现有疫苗卡介苗（BCG）对成人肺结核预防效果不佳。研究人员开展 MTBVAC 候选疫苗早期免疫应答研究。结果显示，MTBVAC 激活了 CD4 和 γδ T 细胞等，该研究为疫苗评估提供依据，助力 TB 防控。
The Scientist5 年
Resolving Cell Subtype Specialization with scRNA-seq and RNAscope
Resolving Cell Subtype Specialization with scRNA-seq and RNAscope from thescientistllc on Vimeo. Discover how a combination of single-cell RNA sequencing (scRNA-seq) and quantitative RNA in situ ...
来自MSN6 个月
Researchers gain new understanding of how immune cells respond to heat during fever
Researchers cultured murine helper T (CD4-expressing ... Researchers used single-cell ribonucleic acid sequencing (scRNA-seq) datasets from Crohn's disease and rheumatoid arthritis patients ...
来自MSN6 个月
Dietary antigens reduce small intestine cancer by boosting immune T-cells
Single-cell ribonucleic acid sequencing (scRNA-seq) was used to investigate ... cluster of differentiation 4 (CD4)-expressing helper and CD8-expressing cytotoxic T-cells within PPs were reduced ...