肺栓塞（PE）是一种危及生命的疾病，会引发长期并发症，其中就包括残留肺血管阻塞（RPVO）。RPVO 与静脉血栓栓塞复发风险增加、慢性症状以及生活质量下降有关。研究人员推测，内皮激活和血管损伤在 RPVO 的病理生理过程中起着核心作用。这项前瞻性单中心研究旨在探究循环生物标志物，如 CD34?细胞、循环内皮细胞（CECs）和血小板衍生生长因子 BB（PDGF - BB），能否作为血管后遗症的指标以 ...

干细胞因其自我更新与多向分化能力，在再生医学、疾病建模及治疗领域展现出巨大潜力。然而，由于其特殊的生物学特性，例如相对静息状态、高效外排机制、独特的膜性质及对外界刺激的高敏感性等，传统方法如电转，虽能实现一定的基因递送效率，但不仅对细胞损伤大，影响后 ...

“Gene therapy for hemophilia A with the use of lentiviral vector-transduced autologous HSCs resulted in stable factor VIII ...

Results from the single-arm open-label trial have been able to elicit an extension of CD34+ cells ex vivo in two out of the 12 patients enrolled on the trial. The trial data, published in the New ...

In the study, "Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A," published in The New England Journal of Medicine, researchers used a lentiviral vector to deliver gene ...

Pain and clinical scores were calculated for each patient. Image analysis to calculate area percent for TLR-2 and CD34 immuno-expression was performed. Data was tabulated and statistically analyzed.