The proto-oncogene c-MYC encodes a transcription factor that is implicated in various cellular processes ? cell growth, proliferation, loss of differentiation and apoptosis. c-MYC activates a ...

c-MYC has a pivotal function in growth control, differentiation and apoptosis, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitizes cells to apoptosis by ...

During the progression of gastric cancer, genetic factors play an indispensable role. c-Myc, an oncogene, is abnormally highly expressed in a variety of tumors, including gastric cancer.

UC researchers have found how the MYC oncogene fuels lymphoma by altering cell metabolism, paving the way for targeted ...

and c-Myc in 49 consecutive liver biopsies with nonalcoholic fatty liver disease (NAFLD) using immunohistochemistry. "The aim of this study was to determine the relationships between p-STAT3 ...

The protein c-MYC plays a central role in the regulation of basic cellular processes and is essential for cell proliferation. However, under certain circumstances, it can initiate a positive ...

Ryo Miyake) in the University of Tokyo that the efficacy of polymeric nano-micelles with different drug activation profile depends on the expression level of c-Myc, one of the major proto-oncogene ...

A research team has developed a new class of compounds that effectively inhibit both wild-type CDK9 and its drug-resistant ...

The study shows that target c-Myc molecular glue compound has great potential, which could provide more directions for overcoming resistance issues of CDK4/6 inhibitors in various tumor fields.

Medulloblastomas are one of the most common childhood brain cancers. University of Michigan researchers have now identified a ...

Breast cancer is the most frequent malignancy among women worldwide, and all subtypes of breast cancer involve upregulation of the c-Myc gene, making it a compelling therapeutic target. G-rich regions ...

and follicular hyperplasia (right); there is bright nuclear staining of MYC protein in Burkitt's lymphoma cells, compared with < 5% of benign germinal center B cells stained for MYC (right). (B) MYC ...