Many millions of times per day, football-shaped structures called mitotic spindles form within the body’s cells as they prepare to divide. The process is routine but mysterious, as the micro-mechanics ...

The mitotic spindle includes thousands of microtubules, ... "This is a way by which the cell can tune the amount of force it needs in order to build a nice balanced spindle structure," Forth says.

During cell division, the motor protein kinesin-5 hastens or retards microtubule sliding in the mitotic spindle, imparting forces that scale with the degree of microtubule overlap.

In research published October 1 in Developmental Cell, scientists at The Rockefeller University reveal new insights into the mechanical forces that govern elements of the mitotic spindle formation ...

Flip of mitotic spindle has disastrous consequences for epithelial cells Date: July 21, 2013 ... Constructing a body is like building a house -- if you compromise structural integrity, ...

A flip of the mitotic spindle has disastrous consequences for epithelial cells ... KANSAS CITY, MO—Constructing a body is like building a house—if you compromise structural integrity, ...

A, The hidden, dynamic nature of the spindle.The spindle contains different subpopulations of microtubules — kinetochore microtubules (1), interpolar microtubules (2) and astral microtubules (3).

Research My current research includes building coarse-grained models and simulations of cytoskeletal filaments and their associated motor proteins with the aim of better understanding the role of ...

Constructing a body is like building a house—if you compromise structural integrity, ... A flip of the mitotic spindle has disastrous consequences for epithelial cells.