At least three morphologically distinct sub-populations of microtubules exist within mitotic spindles ... In combination, these findings build a picture of the spindle as a remarkably dynamic ...

To better understand the role of kinesin-8 proteins in mitosis, we have studied the effects of deletion of the fission-yeast kinesin-8 proteins Klp5 and Klp6 on chromosome movements and spindle length ...

The spindle assembly checkpoint arrests mitotic progression until each kinetochore secures a stable attachment to the spindle. Despite fluctuating noise, this checkpoint remains robust and ...

Many millions of times per day, football-shaped structures called mitotic spindles form within the body’s cells as they prepare ... “This is a way by which the cell can tune the amount of force it ...

Their work focuses on the motor protein, kinesin-5, which helps to organize the spindle's filaments. Many millions of times per day, football-shaped structures called mitotic spindles form within ...

Many millions of times per day, football-shaped structures called mitotic spindles form ... amount of force it needs in order to build a nice balanced spindle structure," Forth says.

Richard McIntosh, Matthew A. Glaser, and Meredith D. Betterton (2017). Science Advances3, e1601603. DOI: 10.1126/sciadv.1601603. Download. Mitotic spindles use an elegant bipolar architecture to ...

view more KANSAS CITY, MO—Constructing a body is like building a house—if you compromise ... of Nature demonstrate that the way the mitotic spindle—the machinery that separates chromosomes ...

Constructing a body is like building a house—if you compromise ... online issue of Nature demonstrate that the way the mitotic spindle—the machinery that separates chromosomes into daughter ...