生物通报道 来自首都医科大学和杜克大学医学院的研究人员展开合作，在新研究中生成了关于一种罕见且致命的儿童及青少年脑癌形式：脑干胶质瘤（brainstem glioma）的一些遗传新见解。 研究人员确定了肿瘤细胞中的一种遗传突变对细胞的生长和死亡均起作用。

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas. Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect.

Pediatric brainstem glioma is an incurable malignancy because of its inoperability. As a result of their extensive tropism toward cancer and the possibility of autologous transplantation, human ...

Brainstem gliomas account for approximately 20% of all CNS tumors among children younger than age 15. 1 This increase from 10% in the late 1970s reflects an increase in detection of the nondiffuse ...

Brain stem gliomas are growths that begin in the glial cells of the brain stem. Doctors can diagnose brain stem glioma using neurological exams and scans. Treatment may involve chemotherapy ...

The diagnosis of brainstem glioma was long considered a single entity. However, since the advent of magnetic resonance imaging in the late 1980s, neoplasms within this anatomic region are now ...

“Brainstem high-grade gliomas are among the rarest and deadliest lesions that pose significant treatment challenges,” Adham Khalafallah, MD, postdoctoral research fellow . News ...

This case is of a diffuse brainstem glioma with pontine involvement as demonstrated by the imaging seen in the figure. Diffuse intrinsic brainstem gliomas represent 75% of all brainstem tumors.

New Chemotherapy Regimen Prolongs Survival In Difficult-to-treat Childhood Brainstem Gliomas. ScienceDaily . Retrieved June 3, 2025 from www.sciencedaily.com / releases / 2007 / 09 / 070925095353.htm ...

Glioma is a broad category of brain and spinal cord tumors that come from glial cells – brain cells that support nerve cells. The symptoms, prognosis, and treatment of a glioma depend on the ...

Most childhood brain stem gliomas are pontine gliomas, which form in a part of the brain stem called the pons. Although cancer is rare in children, brain tumors are the most common type of ...