Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

When blood cancer cells break through the bone and multiply, tumor cells become dangerously diverse and the immune response ...

Immune cells in the bone marrow microenvironment of AML patients are key in distinguishing a response to immunotherapy.

More information: Tongling Huang et al, Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow, Nature Communications (2024). DOI: 10.1038/s41467-024 ...

Pharmatest Services has announced it has collaborated with Taconic Biosciences to develop a novel humanised mouse model of tumour ...

The team identified that a key cell type in the DLI product and features of the tumor microenvironment in patients both play a role ... To do this, they examined cells from the bone marrow of 25 ...

Our goals are to pioneer the development of biomaterial systems for 3D cell culture to further fundamental understanding of how cells receive and exchange information with their extracellular ...