Immune cells in the bone marrow microenvironment of AML patients are key in distinguishing a response to immunotherapy.

Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

When blood cancer cells break through the bone and multiply, tumor cells become dangerously diverse and the immune response ...

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The team's new device is a small plastic chip whose specially designed chambers are filled with human blood stem cells and the surrounding support cells with which they interact in a hydrogel to mimic ...

Discover how groundbreaking research on unique immune cells and advanced AI tools offers renewed hope for improving cancer ...

The team identified that a key cell type in the DLI product and features of the tumor microenvironment in patients both ... To do this, they examined cells from the bone marrow of 25 patients with ...

More information: Tongling Huang et al, Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow, Nature Communications (2024). DOI: 10.1038/s41467-024 ...