(3) There are many steps at which the biogenesis of different small RNA substrates can be regulated by trans-acting factors. Figure 1. Complexity of small RNA processing and loading pathways. This ...

miRNAs are transcribed from a gene and processed by DCL1, SE and HYL1 into an RNA duplex (miRNA/miRNA*). The duplex is methylated by HEN and transported out of the nucleus by HST. The miRNA ...

Figure 1: Phenotypes of lin-4 and lin-14 mutants. Why was I so pessimistic about the prospect of lin-4 being the harbinger of a diverse class of regulatory molecules of broad importance?