In cases of a condition called jaundice, a compound called bilirubin turns a person's skin and eyes yellow. It's usually a ...

Biliverdin reductase catalyses the last step in haem degradation and produces the major lipophilic antioxidant bilirubin via reduction of biliverdin, using NAD(P)H as a cofactor. Despite the ...

1995; Yuan et al., 1995). Biliverdin reductase A (BLVRA) is an evolutionarily conserved enzyme that converts biliverdin to bilirubin (Beale and Cornejo, 1984; Schluchter and Glazer, 1997 ...

Scientists say they have new experimental evidence of a novel role for bilirubin, a natural yellow pigment found in the body, ...

New research suggests that a pigment that causes yellowing of the skin, or jaundice, may help protect people from the most severe consequences of malaria.

A research team has investigated biliverdin reductase, the enzyme producing bilirubin -- a substance linked with jaundice -- from biliverdin (BV). Two BV molecules were found at the enzyme ...

This pigment is normally transformed into another substance by a special protein called biliverdin reductase-A (BVR-A). Think of BVR-A as a tiny machine inside the body that converts biliverdin ...

biliverdin can naturally be broken down in the liver by an enzyme called biliverdin reductase, which also exists in other organs throughout the body," says Parinaz Fathi, graduate student and first ...

To test their idea that these tiny amounts of bilirubin had a big job, the scientists used a research tool called RNA interference to "zip up" the RNA for biliverdin reductase, the enzyme that ...

Led by M.D./Ph.D. candidate David Baraño, the research team demonstrated that, without biliverdin reductase, human cancer cells and brain cells from rats experienced much more damage and cell ...

"Biliverdin reductase: A major physiologic cytoprotectant," Proc Natl Acad Sci, 99:16093-8, Dec. 10, 2002). Using RNAi to block the enzyme that interconverts biliverdin and bilirubin doomed the human ...

Biliverdin is further reduced to bilirubin by the enzyme biliverdin reductase. Carbon monoxide can activate guanylyl cyclase (GC) and lead to the formation of cyclic guanosine monophosphate (cGMP).