This article aims to provide a comprehensive summary of the progress made in GPCRs allosteric modulators in the treatment of neuropathic pain, and discuss the potential benefits and adverse factors of ...

Timothy Clark. During his PhD, Lampros focused on synthesizing allosteric modulators for the human chemokine receptor CXCR3; a G protein coupled receptor known to be involved in multiple autoimmune ...

those given placebo. Treatment with an oral allosteric modulator was nonsuperior to placebo at 6 weeks in adults with Parkinson’s disease whose symptoms included fall risk and cognitive issues ...