This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

In this type of diabetes, the immune system specifically destroys insulin-secreting beta cells in the pancreatic islets — the body's own immune system attacks its own cells (a form of autoimmune ...

After years of controversy, stem cells are on the cusp of cures for conditions like epilepsy and type 1 diabetes.

As it has been established that a few islet antigen–specific T cells in a sea of nonspecific bystanders can drive complete beta-cell destruction 15, the question of whether there is a particular ...

More information: Esra Karakose et al, Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors, Cell Reports Medicine (2024). DOI ...

The islets chiefly contain beta- and alpha-cells that produce the hormones insulin and glucagon, respectively. Insulin is secreted into the bloodstream and acts much like a key to unlock the body ...

Researchers at IISc Bengaluru discover potential drug-free treatment for diabetes by enhancing beta-cell function with small ...

MHH team aims to intervene in the autoimmune process and stop the destruction of insulin-producing beta cells in the pancreas ...

Proven Differentiation Potential: PSXi013 demonstrates robust differentiation potential across a wide array of therapeutically relevant cell types, including but not limited to beta islets ...

In type 1 diabetes, it also evades the autoimmune rejection of pancreatic beta cells. UP421 cells were transplanted with no immunosuppression, and the survival of the islet cells provides evidence ...

The study identified no safety issues, and the HIP-modified islet cells evaded immune responses ... a person’s immune system attacks and destroys the beta cells. Today’s data, when combined ...