In T2D, long-term exposure to high glucose and fatty acid levels (glucolipotoxicity) can ultimately lead to beta cell dysfunction and death. ChREBP is a transcription factor that plays a crucial ...

In this type of diabetes, the immune system specifically destroys insulin-secreting beta cells in the pancreatic islets — the body's own immune system attacks its own cells (a form of autoimmune ...

Researchers have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity - a harmful condition linked to the progression of type 2 ...