4 The exact molecular basis of Atg5/Atg7-independent autophagy remains to be elucidated. Interestingly, Beclin 1 is required for Atg5/Atg7-dependent and -independent autophagy. 3 However ...

Autophagy is the primary cellular catabolic program activated in response to nutrient starvation. Initiation of autophagy, particularly by amino-acid withdrawal, requires the ULK kinases.

The findings reported in the journal Developmental Cell show that autophagy protein Beclin-1 governs endometrial remodeling and the establishment of pregnancy in animal models by regulating ...

They report today in the journal Developmental Cell that autophagy protein Beclin-1 governs endometrial remodeling and the establishment of pregnancy in animal models by regulating autophagy, a ...

They report today in the journal Developmental Cell that autophagy protein Beclin-1 governs endometrial remodeling and the establishment of pregnancy in animal models by regulating autophagy ...

Akt may also negatively regulate autophagy by phosphorylating Beclin 1. AMP-activated protein kinase (AMPK), which is regulated by AMP levels, negatively regulates mTOR and also directly ...

Our cells have a housekeeping service called autophagy that cleans up dysfunctional cellular components - essential to maintain cellular health. This cell-maintenance process may have an answer to ...

Autophagy (“self-eating”) is the process ... which comprises ATG14, Beclin 1, VPS34, and VPS15 and generates phosphatidylinositol 3-phosphate (PI3P) on autophagosomal precursor membranes.

Autophagy is a regulated lysosomal pathway whereby long-lived cellular proteins and cytoplasmic organelles are degraded. The beclin 1 autophagy gene is monoallelically deleted in 40-75% of cases ...

In addition, the scientists showed that in mice beclin 1 regulates the buildup of amyloid-β (Aβ) and that boosting autophagy with a beclin 1-expressing lentivirus reduces Aβ pathology. These findings ...

They report today in the journal Developmental Cell that autophagy protein Beclin-1 governs endometrial remodeling and the establishment of pregnancy in animal models by regulating autophagy ...

"Beclin-1 is known to regulate two distinct natural processes called autophagy and apoptosis that help maintain many normal functions in organisms. We investigated whether one of these two ...