We show here that the expression of the autophagy protein Beclin 1 is higher in mammospheres established from human breast cancers or breast cancer cell lines (MCF-7 and BT474) than in the ...

相关研究结果于2023年4月10日在线发表在Developmental Cell期刊上，论文标题为“Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial ...

更棘手的是，RA滑膜组织中纤维母细胞样滑膜细胞(FLSs)的恶性增殖与自噬(Autophagy)-凋亡(Apoptosis)平衡紊乱密切相关——这种失衡被证实与高迁移率族蛋白1(HMGB1)过表达及Beclin 1-Bcl-2复合体结合减少直接相关，但具体调控机制尚未阐明。 针对这一科学难题，西安交通 ...

蛋白Beclin-1通过调节自噬(一种消化和循环细胞成分的自然过程)来控制动物模型中的子宫内膜重塑和妊娠的建立。 在女性的整个生育过程中，子宫内膜(子宫内膜)会经历周期性的重塑。它在月经周期增厚，为胚胎着床做准备，在月经期间没有受精时脱落。 贝勒 ...

8月24日，中山大学潘志忠，林俊忠和彭健宏共同通讯在《Autophagy》在线发表 ... RUBCNL/Pacer通过与BECN1 / Beclin 1相互作用被认为是自噬体成熟的促进子 ...

综上所述，铁死亡与SCIRI密切相关。USP11和Beclin 1之间的相互作用是触发自噬激活、促进自噬铁蛋白降解和导致铁下垂的关键分子事件。了解铁死亡的 ...

Akt may also negatively regulate autophagy by phosphorylating Beclin 1. AMP-activated protein kinase (AMPK), which is regulated by AMP levels, negatively regulates mTOR and also directly ...

The findings reported in the journal Developmental Cell show that autophagy protein Beclin-1 governs endometrial remodeling and the establishment of pregnancy in animal models by regulating ...

They report today in the journal Developmental Cell that autophagy protein Beclin-1 governs endometrial remodeling and the establishment of pregnancy in animal models by regulating autophagy ...

"Beclin-1 is known to regulate two distinct natural processes called autophagy and apoptosis that help maintain many normal functions in organisms. We investigated whether one of these two ...

They report today in the journal Developmental Cell that autophagy protein Beclin-1 governs endometrial remodeling and the establishment of pregnancy in animal models by regulating autophagy, a ...