BRAF, a cellular oncogene and effector of RAS-mediated signaling, is activated by mutation in ∼60% of melanomas. Most of these mutations consist of a V600E substitution resulting in constitutive ...

为解决 BRAF V600E 抑制剂治疗黑色素瘤的耐药问题，研究人员发现联合 CSE 抑制剂可增效，意义重大。 BRAF V600E 抑制疗法对黑色素瘤有一定疗效，但很快就会出现获得性耐药。研究人员通过细胞系、异种移植和患者来源的异种移植 ...

黑色素瘤中广泛存在的 braf 基因突变，会导致 ras-raf-mek-erk（mapk）信号通路持续激活。braf 抑制剂（brafi）和 mek 抑制剂（meki）已被批准用于治疗 braf v600e 黑色素瘤，包括那些在免疫治疗过程中病情仍进展的患者。 然而，患者对这些药物很快产生耐药性，这凸显了开发新治疗策略的迫切需求。

Around 50% of primary melanomas harbour BRAF mutations, but their prognostic impact has not been clear. Recently, a BRAF-V600E mutation-specific antibody has become available for immunohistochemistry.

方法： 从 2016 年 10 月至 2020 年 5 月，回顾性纳入了二代测序检测到 braf 和 egfr 突变的晚期 nsclc 患者。 从 2020 年 6 月至 2021 年 1 月，前瞻性招募在奥希替尼进展后获得 BRAF V600E 突变的 EGFR 突变的患者，以探索 EGFR + BARF 联合抑制的疗效和安全性。

皮尔法伯BRAFTOVI与MEKTOVI联合疗法获欧盟委员会批准，用于治疗携带BRAF V600E 突变 ... in Metastatic BRAF- Mutant Melanoma. Clin Cancer Res. 2017;23(18):5339-5348. 海量 ...

大多数的braf基因突变是v600e突变，这个基因突变靶点也有目前获批的靶向药，也就是braf基因的抑制剂达拉非尼联合mek抑制剂曲美替尼。 还有维罗非 ...

In this open-label study involving 247 patients with metastatic melanoma and BRAF V600 mutations, we evaluated the pharmacokinetic activity and safety of oral dabrafenib (75 or 150 mg twice daily ...

Interestingly, although the most frequent non-V600E/K BRAF mutation in our study was V600G (27.4%), it was identified in only 1% of rare BRAF mutations in Menzer's report and not found in other ...

Kaur et al. addressed the role of the older microenvironment by injecting mouse melanoma cells that had the Braf V600E driver mutation into immunocompetent young or old mice. The tumors in the ...

Melanoma treatment with two cancer drugs – dabrafenib plus trametinib – was found to lead to long-term benefits in about one-third of patients who had melanoma with a BRAF V600E or V600K ...

Melanoma treatment with two cancer drugs – dabrafenib plus trametinib – was found to lead to long-term benefits in about one-third of patients who had melanoma with a BRAF V600E or V600K ...