这篇综述聚焦慢性髓性白血病（cml），详细阐述了 bcr::abl 激酶相关靶向治疗。从 cml 发病机制、bcr::abl 蛋白异构体，到现有酪氨酸激酶抑制剂（tkis）治疗及耐药原因，还介绍了新兴疗法，为 cml 治疗研究提供了全面参考。

In this Review, the key signalling pathways that lie downstream of the pre-B cell receptor (BCR) and the BCR are discussed in terms of their contribution to B cell homeostasis and neoplasia, with ...

这说明 abcs 的 bcr 内化过程具有独特性，可能与持续的抗原识别有关。 无反应性 B 细胞优先分化为 ABCs ：研究人员利用 MD4 小鼠模型和 MD4×ML5 小鼠模型进行研究，发现 ABCs 在衰老的野生型小鼠中可以产生，但在 MD4 小鼠中却无法产生，而 MD4×ML5 小鼠随着年龄增长会出现明显的 ABCs 生成。

BCR基因在22q11.2处的断点是可变的，ABL1基因在9q34.1处的断点相对稳定，从而形成3种不同的编码蛋白，分别为p190（小断点簇区），p210（大断点簇区 ...

The B cell receptor (BCR) signaling pathway regulates B cell activation, and Fc receptor-like proteins may contribute to this pathway’s activation or inhibition. Previous studies have demonstrated ...

BCR, B cell receptor; VAF, variant allete frequency. We then screened all genetic alterations acquired during BCR inhibition to identify those that might drive resistance. We identified 34 ...

BCR-ABL, a constitutively ... Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines. Blood 2000;95:3498-3505. Crossref. PubMed. Web of ...

This signal results in continuous cell growth and replication. 5 Retroviral transfection with BCR-ABL alone is sufficient to initiate a myeloproliferative disorder in murine models, 6,7 a finding ...

Median expression for each gene was compared across two BCR isotype groups utilizing fisher’s exact test. Results: Our cohort (n = 44) comprised of IgG + (n = 13; 30%) and IgM + (n = 31; 70%) DLBCL ...

The truck portion of the TruckHouse BCR is an AEV Prospector XL.Starting with a Ram 3500 cab-chassis truck (the camper takes the place of the bed), AEV massages the Ram to fit natural-looking 40 ...