B-cell maturation antigen, or BCMA, is selectively expressed when plasma cells differentiate. It is almost absent on memory and naive B cells. The maintenance of long-lived plasma cells involves ...

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy, with disease progression ranging from slow and indolent to ...

Plasma cells (PCs) are the terminal differentiation stage of activated B cells and serve as crucial effector cells in humoral immunity. While PCs have ...

In striking contrast to the conventional plasma membrane FcRs ... the analysis of intracellular signaling processes that promote B cell activation, survival and differentiation. The laboratory has a ...

Induces potent and long-lasting immune responses to defined antigens or whole pathogens (particles), mainly through the ...

The aim of this project is to understand the structure and function of epigenome loops for cell differentiation.We will focus on the differentiation of plasma cells, which produce antibody, as a model ...