They’re also often resistant to treatments, including a common class of antifungals called azoles. Subscribe to Technology Networks’ daily newsletter, delivering breaking science news straight to your ...

They're also often resistant to treatments, including a common class of antifungals called azoles. The study suggests that bisphosphonates could be repurposed to use with azole antifungals ...

fumigatus treatment. The antifungal research and development pipeline, however, includes several promising agents that may improve treatment of azole-resistant aspergillus infections, as well as ...

The drugs are categorized by their specific mechanism of action and can be broken down into four general groups: polyene antifungals, azole antifungals, antimetabolite antifungals, and echinocandins.

The compound is a novel azole with activity about 100-fold more against Aspergillus fumigatus than voriconazole, the leading treatment currently. PC945 also reduced inflammation in the lung. PC945 ...

CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles. Nature Communications , 2024; 15 (1) DOI: 10.1038 ...