In 1981, the first azole antifungal, the diazole ketoconazole, was introduced to the market; then, in the early 1990s the first-generation triazoles, fluconazole and itraconazole, became available.
While occurrence and risks of azole antifungals in wastewater and meat industry have been studied, their presence in surface water and potential threats to water quality are underexplored. This ...
Fluconazole, a very safe and effective azole antifungal, requires a much higher dose in children (12 mg/kg/day) compared with adult patients. In addition, the neonatal field is exploring ...
More information: Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance, Nature Communications (2024).
The findings, reported in Nature Communications, also solve a decades-long scientific puzzle that's prevented drugmakers from successfully using azole antifungal drugs to treat visceral ...