【导读】自噬是一种高度保守的细胞过程，对于维持细胞内稳态以及影响癌症的发展至关重要。3月25日，南昌大学/南方科技大学研究人员合作共同在期刊《Cell Death&Disease》上发表了研究论文，题为“ATP6AP1 promotes cell ...

As we begin to define the role of tumour cell metabolism in response to stress, the rational ability to modulate the autophagy pathway in cancer therapy is emerging. Figure 1: Altered capacity for ...

For example, at the first Keystone Symposium on Autophagy in Health and Disease, held in 2007, Seiji Kondo noted that in the field of cancer research, his colleagues' response when discussing the ...

自噬是一种在真核生物中高度保守的过程，涉及细胞内物质的降解和再循环。它在细胞稳态中起着基础性的作用。大量研究表明，自噬失调与多种疾病明确相关。癌症在发生和发展过程中对能量的需求更大，理论上与自噬的关系更为密切。尽管越来越多的研究表明自噬既可促进也可抑制癌症进展，但癌症与自噬之间的病因学联系仍存在争议。先前的研究表明，PLOD3 可能部分通过自噬途径发挥其生物学功能；然而，其确切机制仍有待阐明。

《Discover Oncology》：Identification of autophagy-related immune targets for enhancing immunotherapy in pancreatic cancer aggressiveness ...

Everyone and their mom seems to be talking about cold plunging right now. Celebs like Kate Middleton and Brooke Shields have ...

2015年9月4日，广东药科大学&暨南大学&广东工业大学在Oncotarget 期刊上在线发表题为 "B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting ...

Each morning for a week, ten young men braced themselves before slipping into tubs of frigid water — just 14 degrees Celsius, ...

The study, published in EMBO Molecular Medicine, shows that a process called chaperone-mediated autophagy (CMA) may function as a natural defense mechanism against metastases. Cancer remains one ...

We are interested in dissecting these mRNA splicing events to understand the pathobiology of endometrial cancer beyond the transcriptional effects of steroid hormones. We also are testing our ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...