免疫组化显示，gdnf+stz组的反应性微胶质细胞比例（iba1r%）与stz组无差异（p>0.05），均显著高于对照组，表明gdnf未能阻断stz诱导的神经炎症级联反应。 讨论部分指出，该研究首次证实AAV9介导的星形胶质细胞GDNF过表达可重塑细胞形态并部分保护认知功能，但其疗效受限于神经炎症的持续存在。

GDNF通过介导DLK1（delta-like 1 homolog）表达来减弱Notch信号，这与GDNF对细胞存活的影响无关。当移植到颈脊髓损伤的啮齿动物模型中时，表达GDNF ...

在表达gdnf的hipsc-npc中通过crispr诱导dlk1基因敲除可削弱对功能恢复的影响，这就证实这种影响部分上是通过dlk1表达介导的。

反应性星形胶质细胞释放的 gdnf 激活神经元 ret 受体促进神经元存活：研究表明，gdnf 主要通过 gfrα1 - ret 信号通路发挥作用。 对经历 OGD 的神经元进行研究发现，ACM（OGD）处理可显著增加 RET 受体的磷酸化水平，提高 p - RET/RET 比值，表明反应性星形胶质细胞释放的 GDNF 可激活神经元 RET 受体。

A strocytes quickly respond to trouble in the brain. Under normal physiological conditions, these abundant reactive glial cells rapidly adapt to environmental changes, which allows them to regulate ...

In a recent review published in Experimental & Molecular Medicine, researchers reviewed existing data on the neurodegenerative effects of astrocyte-derived lipocalin-2 (LCN-2). Study: Lipocalin-2 ...

A brimming inbox on Monday morning sets your head spinning. You take a moment to breathe and your mind clears enough to survey the emails one by one.

Serotonin triggers changes in astrocyte gene expression patterns, turning astrocytes into a hub of olfactory sensation processing,” Sardar said. “This project has uncovered novel aspects of astrocyte ...

Here is an important reason to stay in touch with friends and family: social isolation causes memory and learning deficits and other behavioral changes. Many brain studies have focused on the ...

Astrocyte cells critical for learning skilled movements Date: March 10, 2023 Source: Picower Institute at MIT Summary: When astrocyte function is disrupted, neurons in the brain's motor cortex ...

A lesser-known type is the astrocyte, a somewhat star-shaped cell that secretes proteins critical for proper brain development. Astrocytes “tell the neurons what to do,” says Nicola Allen, ...