On page 1086, Kuroiwa et al. describe a chromosome-cloning system that can handle large segments of genomic DNA. They cloned large fragments of human chromosomes into a mitotically stable human ...

View Full Profile. Learn about our Editorial Policies. Earlier methods to synthesize HAC relied on linking shorter DNA constructs into a larger chromosome within the cell in a process called ...

To tackle the conundrum, Yingjin Yuan, a professor of biochemical engineering at Tianjin University, turned to deoxyribonucleic acid (DNA) and has designed yeast artificial chromosomes as a ...

Artificial chromosomes are essentially miniature versions of real chromosomes that can replicate alongside their natural counterparts in host cells. They have the potential to be “incredibly useful ...