Whereas the role of APOE in lipid metabolism is well characterized, the specific metabolic signatures of the APOE isoforms during metabolic disorders, remain unclear. After a 4-h fast, animals ...

Apolipoprotein E (apoE), a crucial glycoprotein in CNS lipid metabolism, particularly its apoE4 isoform, significantly influences AD pathogenesis by affecting lipid-binding properties and impairing Aβ ...

It was found that genes related to lipid metabolism were activated shortly ... mice showed that although VLDL levels decreased, apolipoprotein E (ApoE)-a component of VLDL-rapidly increased.

Our data show as a proof-of-principle that psychotropic drug-induced stimulation of cellular lipid biosynthesis in ... transport and -efflux, including ApoE. Such drug-effects could influence ...