为探究载脂蛋白 E（APOE）基因型对阿尔茨海默病（AD）生物标志物进展的影响，研究人员分析 100 名认知正常和轻度认知障碍参与者的纵向数据。结果发现 APOE ε4 携带者伴记忆衰退时，β 淀粉样蛋白（Aβ）积累和灰质（GM）萎缩更明显，该研究有助于优化早期干预 ...

研究结论和讨论部分指出，APOE4 在小胶质细胞中的病理作用可能是通过损害自噬以及相关的 Aβ 斑块清除能力来实现的。这一发现揭示了 APOE4 与小胶质细胞自噬活性之间的直接联系，意味着可以通过诱导自噬的药物治疗来对抗 APOE4 的病理影响，例如雷帕霉素。这为 APOE4 相关的 AD 脑部病理治疗提供了新的思路和潜在的治疗方法，有望为 AD 患者带来新的希望。

Plaques all but vanish in response to some Aβ immunotherapies. Scientists suspect microglia orchestrate the mop-up, but don’t know how, exactly. Now, David Gate of Northwestern University in Chicago ...

Amyloid beta (Aβ) plaques are protein deposits that accumulate in the brains of individuals with Alzheimer’s disease and, to a lesser extent, in several other types of age-related dementias ...

A genetic variant previously associated with a dramatic increase in Alzheimer’s risk may protect against age- and disease-related cognitive decline, a study published in Nature Aging this week ...

The pathological hallmarks of Alzheimer's disease (AD) are amyloid-β (Aβ) plaques and Tau-containing neurofibrillary tangles. Although the relationship between neuronal loss and the presence of ...

“It is generally believed that some form of the aggregated Aβ peptide leads to Alzheimer’s disease, and it’s conceivable that different fibril structures could lead to neurodegeneration with different ...