Problems with the primary sequence of a protein ... on its robust engineering technology underpinning bi-specific antibody design. The team has developed a knobs-into-holes (KIH) engineering ...

Using in silico tools, Ab Studio interrogates primary and tertiary antibody sequences and models to ... with complementary ‘knob into hole’ design that favors formation of the desired ...

These regions display remarkable sequence variability, making it challenging to model them using conventional methods. Traditional approaches for antibody design, such as immunization and phage ...

The sequence homology is over 95%; PTM and aggregation prediction reports are also available 100% success rate As quick as 3–4 weeks to offer required humanized antibodies Affinity evaluated by ...

Generate Bio uses a combination of sequence and structure-based approach towards de novo design of a variety of proteins, including antibodies with desired properties. In addition to its ...

It has been estimated that the human immune system can produce up to 1 quintillion different antibodies by changing the sequence of these amino acids, helping to ensure that the body can respond ...

The scientists fed the sequence of the mouse version of this ... new tool that could significantly accelerate the design of new antibody-based drugs, as well as lower development costs.