A better understanding of the molecular mechanisms leading to aneuploidy holds promise for the development of cancer drugs that target this process. Another example of cancers without aneuploidy ...

"For a long time, we could observe aneuploidy but not manipulate it. We just didn't have the right tools," said Sheltzer, who is also a researcher at Yale Cancer Center. "But in this study ...

A new tool generates and labels customized aneuploid cells in living tissue to observe the behavior of these cells in ...

Alterations in chromosome number can play a role in cancer progression. An analysis of recurrent aneuploidies, such as the duplication of the long arm of chromosome 1, revealed that it was required ...

Healthy human cells have 23 pairs of chromosomes, but it’s been observed for over a century that the majority of cancer cells have extras. This condition is known as aneuploidy, but its exact ...

The findings, said the researchers, suggest that selectively targeting extra chromosomes may offer a new route for treating cancer. The study was published July 6 in the journal Science. Human cells ...

whether they cause cancer or are caused by it. "For a long time, we could observe aneuploidy but not manipulate it. We just didn't have the right tools," said Sheltzer, who is also a researcher at ...

Researchers used CRISPR technology to remove entire chromosomes in melanoma, gastric cancer, and ovarian cell lines Eliminating aneuploidy compromised cancer cells' ability to form tumors ...

resulting in an extra or missing copy — known as aneuploidy. "This was very unexpected," study co-author Nicholas Navin, a professor at the University of Texas' MD Anderson Cancer Center ...

But for decades, researchers have debated whether aneuploidy promotes the growth of cancers, or is simply a side effect of cancer cells' fast growth. Such large-scale changes in DNA have been ...

We recently assessed whether an esophageal brushing that widely sampled the esophagus could be combined with massively parallel sequencing to interrogate ~350,000 genome-spanning regions and identify ...