These fragments aggregate into amyloid fibrils, forming cellular inclusions that are hallmarks of HD pathology. The propensity of polyQ proteins to aggregate correlates with tract length, which ...

For each structural strain of tau fibrils, they identified amino acids without which the strain cannot form its signature ...

Amyloid plaques comprising tangled fibrils of misfolded proteins are well-known drivers of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease, but they are also present ...

In previous research, the team loaded cultured microglial cells with smaller bits of plaques, called amyloid fibrils. When the researchers did this, the cells took a long time to break them down ...

Learn about our Editorial Policies. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and researchers now attribute its symptoms to the deposition of tau amyloid fibrils. Although ...

This nuclear imaging technique is less invasive, but still requires injection of a radioactive tracer molecule (TC-PYP), which binds to amyloid fibrils and allows for their detection throughout ...

The kinetics of fibrillization in dilute aqueous solutions of the protein was monitored as a function of incubation time using the dye thioflavin T, which binds to amyloid fibrils but not to ...

Arctic therapeutics raises funding from EIC Fund, Kaldbakur, and Sanos Group to advance its dementia treatment, AT-001, and acne drug, AT-004. The company aims to transform the treatment landscape for ...

Exercise may positively influence the interactions between brain cells in the hippocampus, a brain region involved in ...

A novel wireless photothermal DBS nanosystem uses nanoparticles to target and restore damaged neurons in Parkinson’s disease, ...

A research team led by Prof. CHEN Chunying from the National Center for Nanoscience and Technology of the Chinese Academy of Sciences designed a wireless photothermal DBS nanosystem, Au@TRPV1@β-syn ...