Amyloid plaques comprising tangled fibrils of misfolded proteins are well-known drivers of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease, but they are also present ...

For each structural strain of tau fibrils, they identified amino acids without which the strain cannot form its signature ...

The kinetics of fibrillization in dilute aqueous solutions of the protein was monitored as a function of incubation time using the dye thioflavin T, which binds to amyloid fibrils but not to ...

This manuscript describes the identification and characterization of 12 specific phosphomimetic mutations in the recombinant full-length human tau protein that trigger tau to form fibrils. This ...

These fragments aggregate into amyloid fibrils, forming cellular inclusions that are hallmarks of HD pathology. The propensity of polyQ proteins to aggregate correlates with tract length, which ...

In previous research, the team loaded cultured microglial cells with smaller bits of plaques, called amyloid fibrils. When the researchers did this, the cells took a long time to break them down ...

View Full Profile. Learn about our Editorial Policies. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and researchers now attribute its symptoms to the deposition of tau amyloid ...

Arctic therapeutics raises funding from EIC Fund, Kaldbakur, and Sanos Group to advance its dementia treatment, AT-001, and acne drug, AT-004. The company aims to transform the treatment landscape for ...

This nuclear imaging technique is less invasive, but still requires injection of a radioactive tracer molecule (TC-PYP), which binds to amyloid fibrils and allows for their detection throughout ...

Exercise may positively influence the interactions between brain cells in the hippocampus, a brain region involved in ...

A novel wireless photothermal DBS nanosystem uses nanoparticles to target and restore damaged neurons in Parkinson’s disease, ...