A bacterium makes a molecule that kills drug-resistant fungi in an unusual way — by targeting various phospholipid molecules in membranes.

Mandimycin is structurally similar to the last-line-of-defense antifungal amphotericin B, another glycosylated polyene macrolide. But instead of binding to ergosterol in the fungal cell membrane as ...

This mode of action means that it is effective against fungal pathogens that have evolved resistance to existing antifungal ...

Mandimycin, which targets a different essential fungi cell resource than other antifungal drugs, should harm other cell types as collateral — but doesn’t.

Candida infections are on the rise globally ... For severe cases, liposomal amphotericin B remains a key treatment option. Newer antifungals, such as ibrexafungerp and oteseconazole, are ...

In a trial of 128 patients with Candida esophagitis, clinical response rates were higher with caspofungin acetate 50 or 70 mg/day (85%) than with amphotericin B 0.5 mg/kg/day (67%). Most enrolled ...

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