A Single Dose of Amphetamine Alters Glutamatergic Synapses in the VTA. We found that a single dose of amphetamine was sufficient to produce enhanced ambulation to an amphetamine challenge 24 h later.

Amphetamine is a powerful stimulant that increases levels of chemicals like dopamine and norepinephrine in the brain. While it can temporarily enhance focus or alertness, it also has well ...

Amphetamine dramatically and rapidly induces the release of norepinephrine and dopamine (and serotonin) into the synapse and greatly slows their inactivation by blocking reuptake back into the neuron.