or at alterations causing complex changes in the amino acid sequence (complex_aae). MutationTaster can be used via an intuitive web interface to analyze single mutations as well as in batch mode.

Li, C. H., Geschwind, I. I., Cole, R. D., Raacke, I. D., Harris, J. I., and Dixon, J. S., Nature, 176, 687 (1955).

This process, known as condensation or dehydration synthesis, results in the formation of a linear chain of amino acids. The sequence of amino acids in a protein, known as its primary structure, ...

Enzymes originally evolved in high-temperature environments and later adapted to lower temperatures as Earth cooled. Scientists discovered that a key shift in enzyme function occurred over ...

Together they developed a technique that confirmed that amino acids were encoded by a sequence of three nucleotides and revealed the triplet code of ambiguous amino acids. From there, Leder went on to ...