The research, titled "Identifying Allosteric Hotspots in Mycobacterium tuberculosis cAMP Receptor Protein through Structural Homology," was led by Dr. Rodrigo Maillard at Georgetown University ...

Title: QTX3544, a potent and selective G12V-preferring KRAS inhibitor, synergizes with EGFR inhibitors for enhanced anti-tumor activity Date and Time: Wednesday, April 30, 2025; 9:00 AM - 12:00 PM ...

The orally administered, brain-penetrant small molecule is an allosteric protein modulator that restores the function of the lysosomal protein enzyme glucocerebrosidase (GCase) which becomes ...

However, the atom-scale mechanisms underlying these processes remain poorly understood Positive allosteric modulators (PAMs) are compounds that enhance the catalytic activity of a target protein by ...