Despite recent advances in crystallography and the availability of G-protein-coupled receptor (GPCR) structures, little is known about the mechanism of their activation process, as only the β2 ...

This advanced regulation is gradually evolving over 1 billion years leading to the strongest allosteric activation in our human kinase. The researchers discovered that its mechanism is the evolution ...

Ancient origins of allosteric activation in a Ser-Thr kinase Descriptive Transcript. Moving illustrating allosteric network (blue dots are essential residues for allosteric network) for regulation.

Chunhao Zhu, Xiaobing Lan, Zhiqiang Wei, Jianqiang Yu, Jian Zhang, Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain, Acta Pharmaceutica ...

This breakthrough confirms a completely novel allosteric activation mechanism for the GLP-1 receptor, distinct from any previously known approaches.

We are conducting the first time in human phase 1 trial of oral VMD-928, a novel allosteric and irreversible TrkA selective inhibitor. Methods: This is an open label, Phase 1 study investigating the ...

Addex receives CHF5M and 20% share of Neurosterix Perceptive Advisors leads $63M investment into Neurosterix Addex contributes portfolio of preclinical neuroscience assets and allosteric modulator ...

“This is the second allosteric TYK2 inhibitor we have advanced into the clinic this year, after SUDO-286 which is progressing in two Phase 1 trials as a topical treatment for psoriasis.” ...