Null alleles have posed recurring challenges for population genetics following the introduction and application of each new method of molecular assay (including serological typing, protein ...

Protective alleles confer protection against disease by disrupting protein function, typically via loss-of-function (LoF) effects. Protective alleles have been identified for a range of complex ...

Plant architecture influences the microenvironment throughout the crop canopy. Plants with a more erect leaf architecture ...

Major-histocompatibility-complex alleles determine the tissue compatibility that is necessary for the acceptance of transplanted tissues. 1 Graft survival after kidney and heart transplantation is ...

Keating D, Marigowda G, Burr L, et al. VX-445–tezacaftor–ivacaftor in patients with cystic fibrosis and one or two Phe508del alleles. N Engl J Med 2018;379:1612-1620. Crossref ...

Throughout Paris Fashion Week, the Washington-based diplomat turned heads in curated ensembles that merged high fashion with ...

The difference is all to do with their genetics. Humans are “diploid” organisms, meaning they have two copies (alleles) of each gene, one from each parent. Bees, however, work a little differently.

Patients who underwent stem cell transplants (SCTs) involving mismatched unrelated donors (MMUDs) had a 1-year overall ...

Every individual has two copies, or alleles, or a single gene. When the alleles are the same, they are known as homozygotes. When they are different, they are called heterozygotes. Homozygotes code ...

Loss-of-function alleles are more common in certain ethnic groups, such as people with an Asian ethnic background. The Clinical Pharmacogenetics Implementation Consortium's guideline for clopidogrel ...

There are two basic alleles, short and long (the long gene has 14 repeats of the same sequence while the short gene is 12), so three genotypes (as we get one from mom and one from dad) are: short ...

Since these alleles have been around for more than 5000 years, they may in fact have some evolutionary advantage. “Common [gene] variants have subtle roles across the genome, affecting multiple ...