This review discusses the role of aldosterone antagonists in the treatment of heart failure, including an overview of aldosterone’s role in the pathology of heart failure, the benefits of each ...

[36] Spironolactone (Aldactone, an aldosterone receptor blocker, can be used in the presence of heart failure to diminish the degree of potassium loss or to increase net diuresis in patients with ...

Sodium reabsorption is mainly controlled by aldosterone, a steroid hormone synthesized in the zona glomerulosa of the adrenal gland, secondary to renin stimulation via angiotensin II and to ...

Activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) occur in patients with systolic heart failure. Then mainstay of therapy for this disorder is ...

Aldosterone antagonists (spironolactone ... Spironolactone is indicated (class IIa, level of evidence B) in systolic heart failure with recent or current New York Heart Association functional ...

Spironolactone's safety profile had been primarily generated from trials of older people with heart failure, so its safety in ...