ALDH-1 Expression is Associated with Increased Breast Cancer Risk. ALDH-1 showed cytoplasmic expression in epithelial cells as described previously. 6, 16, ...

The study also shows how the ALDH gene and its protein act to create a cell's stem-like properties. "One way ALDH makes a cancer stem cell is through the retinoic acid signaling pathway," Fujita says.

ALDH activity characterizes normal stem cells and cancer stem cells (CSCs) in several human malignancies, including pancreatic adenocarcinoma; however, the clinical significance of ALDH-expressing ...

From this cohort, adjuvant treatment information was available for 87 patients with ALDH-negative tumors (48.6%) and 41 patients with ALDH-positive tumors (45.6%). In patients treated with adjuvant ...

“Increased exposure to alcohol, loss of the ALDH gene that helps the body process alcohol, and loss of the ability to repair DNA cross links all result in increased cancer risk.

Magnification: 200×. ALDH, acetaldehyde dehydrogenase. view more . ... Understanding their distribution and function within the liver is key to addressing liver diseases, including cancer.