ALDH-1 Expression is Associated with Increased Breast Cancer Risk. ALDH-1 showed cytoplasmic expression in epithelial cells as described previously. 6, 16, ...

The study also shows how the ALDH gene and its protein act to create a cell's stem-like properties. "One way ALDH makes a cancer stem cell is through the retinoic acid signaling pathway," Fujita says.

ALDH activity characterizes normal stem cells and cancer stem cells (CSCs) in several human malignancies, including pancreatic adenocarcinoma; however, the clinical significance of ALDH-expressing ...

In patients treated with adjuvant CRT, median overall survival was superior in the ALDH-negative cohort vs. the ALDH-positive cohort, 26.3 months vs. 18.2 months (p=0.011). Further, in patients ...

“Increased exposure to alcohol, loss of the ALDH gene that helps the body process alcohol, and loss of the ability to repair DNA cross links all result in increased cancer risk.

For decades we have known that alcohol consumption increases a person’s risk of developing cancer, but how this actually occurs has never been completely understood. Now a team has demonstrated ...

A shortage of the enzyme ALDH-2, which is needed to break down alcohol in the body, causes a buildup of the cancer-linked chemical acetaldehyde, perhaps explaining why alcoholics lacking ALDH-2 ...

Magnification: 200×. ALDH, acetaldehyde dehydrogenase. view more . ... Understanding their distribution and function within the liver is key to addressing liver diseases, including cancer.