PI3K/AKT 信号通路参与调节细胞的糖代谢 ... 图. BZA-enhanced 5-FU-induced cell apoptosis is partly related to the Bad/Bcl-2 signaling pathway in colon cancer HT29 and SW480 cells ...

The AKT/PKB (protein kinase B) kinases, which include AKT1, AKT2, and AKT3, are key intermediates of signaling pathways that regulate cellular processes controlling cell size/growth, proliferation ...

Explore how cutting-edge agents like alpelisib, capivasertib, MEK and ERK inhibitors, and JAK inhibitors are reshaping the ...

As a consequence, phosphorylation of TCR proximal signaling molecules, including Lck and ZAP-70, is impaired (Panel A). Activation of the PI3K–Akt–mTOR pathway (Panel B) and activation of the ...

AKT pathway activation is implicated in endocrine-therapy resistance. Data on the efficacy and safety of the AKT inhibitor capivasertib, as an addition to fulvestrant therapy, in patients with ...