Malignant gliomas and medulloblastomas — the most common brain tumours affecting adults and children, respectively — remain responsible for a disproportionate level of morbidity and mortality ...

Let’s hear the thoughts of some of the world’s leading glioma experts on the data from the study A Multilingual Overview of the INDIGO Study Data (Presented by Clinical Experts in French ...

Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis. Previous research suggests that platelet-derived growth ...

Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors found in the pontine region of the brainstem. Due to their high intratumoral genetic and cellular heterogeneity and ...

Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are ... a multifaceted role in the pathogenesis of both adult and pediatric high-grade gliomas.

The FDA is currently reviewing this drug under the accelerated approval pathway as a potential treatment for adult and pediatric patients with recurrent H3 K27M-mutant diffuse glioma. A final ...

New Drug Application (NDA) for Dordaviprone as Treatment for Recurrent H3 K27M-Mutant Diffuse Glioma Under Review with Prescription Drug User Fee ...

Chimerix's lead clinical asset is dordaviprone, a novel first-in-class small molecule treatment in development for H3 K27M-mutant diffuse glioma, a rare, high-grade brain tumor that most commonly ...