Ferroptosis impacts immune responses by reducing immune cell numbers and altering their functions. While some studies suggest it may enhance immunity, the overall effect is immunosuppressive.

A registry analysis of Chinese adults with type 2 diabetes suggests that a higher concentration of circulating adiponectin, a protein typically associated with reduced cardiovascular risk ...

Adiponectin is a peptide hormone secreted by the adipocytes. Other cells such as skeletal and cardiac myocytes as well as endothelial cells also produce adiponectin. This hormone plays a key role ...

A research team from Emory University School of Medicine investigated the role between adiponectin and leptin in obesity-related carcinogenesis. Their findings, published in the November issue of ...

Objective: Adiponectin, synthesized in the adipose tissue, appears to play an important role in hyperglycemia and dyslipidemia, as well as in inflammatory mechanisms, which lead to a markedly ...

All of our current oncology drugs push tumors to their demise through a process called apoptosis, but some cancer cells alter their gene expression to become reliant on ferroptosis, explains ...

This graphical abstract shows how T-cells alter the metabolism of amino acids to cause ferroptosis. [University of Michigan Rogel Cancer Center] “Cancer immunotherapy restores or enhances the ...

Researchers report on a newly discovered biochemical pathway that protects cells from a type of cell death called ferroptosis. The hallmarks of cancer include rapid cell reproduction and metabolic ...

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression. Ferroptosis, driven by excessive lipid peroxides and iron-dependent ...

Patrizia Agostinis (VIB-KU Leuven) has found that melanoma cell populations protect themselves from a form of cell death called ferroptosis by secreting the lipoprotein apolipoprotein E (ApoE).