The family of adhesion G protein-coupled receptors (aGPCRs) represents the second largest class of GPCRs, and aGPCRs have ... for human health and disease. In this Review, we discuss the current ...

Adhesion G protein-coupled receptors (GPCRs) are a group of cell-surface sensors associated with many body functions and ...

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies. Collaborative ...

This genetic disease causes fluid-filled cysts to form in the kidneys ... Generic residue numbering of the GAIN domain of adhesion GPCRs. Nat Commun. 2025;16(1):246. doi: 10.1038/s41467-024-55466-6 ...

Diseases associated with mechanosensitive adhesion G protein-coupled receptors ... As a distinct subgroup of the GPCR superfamily, aGPCRs possess a specialized extracellular domain, enabling ...

the adhesion GPCRs (aGPCRs), is still uncharted pharmacological and pharmaceutical territory. These molecules are associated with a wide range of diseases, from cancer to psychiatric disorders ...

Adhesion GPCRs belong to the large family of G protein ... researchers in this field to gain a deep understanding of human diseases, because the animals are genetically very similar to humans.

Adhesion GPCRs belong to the large family of G protein-coupled receptors ... a model animal allows researchers in this field to gain a deep understanding of human diseases, because the animals are ...

Adhesion GPCRs are a group of G protein-coupled receptors associated with many bodily functions and diseases in humans. Scientists at Leipzig University have discovered a new receptor—which they ...

The characteristic pain crises and organ failure seen in sickle cell disease results from the abnormal red blood cells adhesion to the endothelium of small vessels and subsequent blood flow cessation.