An HEK293-derived cell line was established for the propagation of the E1-deleted Ad35 vector, avoiding the emergence of replication-competent adenovirus. Moreover, production of the E1-deleted ...

Adenoviral vectors have shown great promise ... To clone the foreign gene of interest into the Ad molecular clone, a shuttle vector was used containing two very rare restriction sites, I-CeuI ...

Adenoviral vectors will transduce a wide range of target cells resulting in high-level gene expression. They are non-integrating vectors so expression in dividing cells is progressively lost. First ...

BEIJING -- One more Chinese adenovirus vector vaccine candidate against COVID-19 is ready for human trials at home and abroad, its developers said Monday. Researchers from Tsinghua University ...

As soon as the genetic sequence of SARS-CoV-2 was posted online in January, three groups began independently working on adenoviral vector vaccines for COVID-19: CanSino Biologics, the University ...

Researchers from Purdue University and the U.S. Centers for Disease Control and Prevention have recently developed a novel influenza vaccine candidate that uses a bovine adenoviral (BAd) vector to ...

Vector-induced antiphospholipid antibodies were detected in 3 of 20 participants. This phenomenon was transient and has been reported previously with adenovirus vectors and licensed vaccines.

Is the relatively low efficacy of adenovirus-based vaccine in some people because of pre-existing antibodies towards the vector? “Adenovirus-based vaccine platforms have been in development for ...

A killed whole-virus vaccine is one of the oldest vaccine technologies. To make such a vaccine for Covid, a manufacturer will grow large quantities of the SARS-CoV-2 virus, and inactivate it using ...

At present, gene transfer mediated by an adenovirus-associated virus (AAV) vector shows the greatest promise for long-term correction of hemophilia B in the preclinical setting. 3–7 However, a ...

AstraZeneca and the University of Oxford offered a promising but confusing early look at late-stage data for their experimental adenoviral vector vaccine for COVID-19. The preliminary results ...

They present a novel adenoviral vector that binds to the EphA2 receptor (EphA2R). This receptor is highly expressed in several solid tumors including pancreatic cancer. YSA, a small peptide ligand ...