“GFAP positivity could help us identify people with brain amyloid who are fated to develop tau pathology,” Pascoal told Alzforum. In preclinical AD, tau phosphorylation ... burden correlate with ...

With the discovery that APP mutations can act as fully penetrant AD genes, a compelling hypothesis known as the amyloid cascade hypothesis was put forward. This hypothesis states in essence that ...

32 Tau tangles and amyloid plaques are not the only features observed in the AD brain; inflammation and oxidative stress also occur. The mitochondrial cascade hypothesis indicates that tau and Aβ ...

Soon after Clifford Jack, Mayo Clinic, Rochester, Minnesota, proposed a hypothetical model showing biomarkers emerging at different stages of Alzheimer’s disease (AD), his diagram ... does not ...

Wang’s study “β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade,” was recently published ... Alzheimer’s disease (AD) is a devastating disease that affects ...

Screening the literature, it may appear that for many in the AD field, the ultimate proof to be right after following the mainstream hypothesis (the "amyloid cascade") for decades is of top ...

"If you have more amyloid ... this graph it almost perfectly parallels the autopsy data. Our data are therefore consistent with the autopsy data suggesting that maybe 15 years before AD develops ...

It's hypothesized that in AD, amyloid triggers a cascade of events, starting with an increase in phosphorylation of tau, then accumulation of neurofibrillary tangles, with the amyloid and ...

Recent approvals by the Food and Drug Administration have focused on medications that shrink the sticky brain deposits of a protein called amyloid beta. The errant growth of this protein is ...

Currently the most common cause of dementia, AD is a progressive, neurodegenerative disease that causes the brain to shrink and brain cells to die. Accumulation of misfolded amyloid beta is recognised ...