Topline results were announced from a phase 3 study evaluating sotatercept-csrk in recently diagnosed adults with pulmonary arterial hypertension (PAH).

Although Activin/Nodal signaling regulates pluripotency of human embryonic stem (ES) cells, how this signaling acts in mouse ES cells remains largely unclear. To investigate this, we confirmed ...

The ZENITH study found that in high-risk PAH, add-on sotatercept was tied to lower risk for death from any cause, lung ...

In muscle tissue, Activin interacts with the Activin RII receptor, triggering intracellular signaling pathways. Activin RII phosphorylates Activin RI, which activates the Smad2/3 signaling pathway.

However, a better understanding of the downstream signaling pathways contributing ... from COVID-19 patients to see if they had elevated Activin A levels. They also evaluated PAI-1, another ...

Follistatin-344 (FS-344), a glycoprotein variant, has emerged as a focal point in scientific research due to its potential ...

Panelists discuss how riociguat targets the nitric oxide pathway and is approved for both Group 1 PAH and Group 4 chronic ...

The antibody has shown strong efficacy in preliminary studies, capable of blocking Activin E signaling and demonstrating sub-nanomolar potency. Activin E is believed to regulate energy balance ...

iBio plans to rapidly advance testing of the antibody in more complex models following preclinical studies that demonstrated strong antibody binding, inhibition of Activin E signaling and fat ...

Data collected from preclinical studies conducted by iBio show strong antibody binding to Activin E and the ability to block its signaling. The compound discovered by iBio demonstrates exceptional ...