Although Activin/Nodal signaling regulates pluripotency of human embryonic stem (ES) cells, how this signaling acts in mouse ES cells remains largely unclear. To investigate this, we confirmed ...

相比之下，TNFR2 介导的 EAE 诱导的 CNP 减轻与性别和性别染色体无关。然而，在两种不同的神经病理性疼痛模型（EAE 和慢性压迫性损伤）中，TNFR2 激活后 CNP 的减轻依赖于性腺激素 Activin-A。这表明性腺来源的因子通过一种共同机制影响 TNFR2 介导的疼痛缓解 ...

Topline results were announced from a phase 3 study evaluating sotatercept-csrk in recently diagnosed adults with pulmonary arterial hypertension (PAH).

However, a better understanding of the downstream signaling pathways contributing ... from COVID-19 patients to see if they had elevated Activin A levels. They also evaluated PAI-1, another ...

In muscle tissue, Activin interacts with the Activin RII receptor, triggering intracellular signaling pathways. Activin RII phosphorylates Activin RI, which activates the Smad2/3 signaling pathway.

iBio plans to rapidly advance testing of the antibody in more complex models following preclinical studies that demonstrated strong antibody binding, inhibition of Activin E signaling and fat ...

Data collected from preclinical studies conducted by iBio show strong antibody binding to Activin E and the ability to block its signaling. The compound discovered by iBio demonstrates exceptional ...

iBio plans to rapidly advance testing of the antibody in more complex models following preclinical studies that demonstrated strong antibody binding, inhibition of Activin E signaling and fat ...