Cell migration affects all morphogenetic processes and contributes to numerous diseases, including cancer and cardiovascular ... which in turn regulate actin polymerization and myosin II activity ...

These inhibitors aim to halt metastasis by preventing fascin from binding actin filaments and gathering them into bundles within filopodia. Immobilized, the cancer cells are stopped in their tracks.

We want to understand how these changes are co-ordinated by dynamic regulation of the actin cytoskeleton throughout cell division. We are particularly interested in how cells divide within epithelial ...